Assignment 2 Essay Example | Topics and Well Written Essays - 500 words - 12

Assignment 2 - Essay Example Yet, the actual experience of smelling a rose cannot merely be contained and explained through this comprehensive body of information. This in essence is the Qualia problem. Jackson illustrates the inadequacy of physicalism through couple of examples. He uses the ‘knowledge argument’ in describing the case of the exceptionally sighted Fred. Fred actually sees two colors within the conventional red spectrum. In other words, just as a normal human eye can distinguish between yellow and blue clearly and consistently, Fred is able to identify two colors within red – red1 and red2. The nomenclature contains ‘red’ as a common term, but it does not mean Fred sees two shades of red. To him the two are as distinct as yellow and blue are for a normal human being. This much is a brief account of the physical facts of the phenomenon. But crucially, it is a poor substitute for what it is to experience those two different colors. Even the analogy of yellow and blue give a conceptual understanding but no clue as to what the two reds might look like. This is the major shortcoming of physicalism and hence the introduction of qualia into the discussion. I totally agree with Jackson’s emphasis on qualia and its centrality to discussing sensory experience. Physicalism, though, has its utility, in that, it helps document and describe sensory phenomena for scholarly analysis. But it is ultimately limited in capturing the real experience as and when it occurs to a human subject. In my view modern psychology could benefit by incorporating qualia into its therapeutic models. It is widely understood that psychological states like depression and anxiety have their origins in perception. Two different people perceive the same sort of event in two different ways. Their reaction to these events is in turn dictated by their perception. Cognitive Behavioural Therapy (CBT) is aimed toward rectifying the patient’s distorted perceptions of self, others, circumstances and the

Inhibition of DNA processing in heavy metal carcinogenesis Essay

Inhibition of DNA processing in heavy metal carcinogenesis - Essay Example Nonetheless, although it has been noted that some heavy metals may inhibit SSB (single strand break) rejoining, the effects on single strand break end-processing enzymes has never previously been investigated. First, an analysis on the DNA replication as a result of topo-1 enzyme will be done. This will show how topo-1 enzyme is responsible for winding of DNA structures. A picture analysis will be included to show evidence of the process. As mentioned earlier, different heavy metals have effects on the living organism’ DNA. The metals will be discussed together with their effects. This paper also explores inhibition of superoxide dismutases. This enzyme catalysis the dismutation of extremely reactive superoxide ions to generate hydrogen peroxide and numerous lines of evidence propose that these enzymes play significant part in the development and also response to treatment of cancers. These are enzymes that control under-winding and over-winding of DNA. DNA winding comes from the intertwined nature of its double-helical structure. For instance, during replication of DNA, DNA is overwound before a replication fork. When it is not controlled, it will eventually lead to a halt in DNA replication. A similar process is observed during transcription. To overcome the topological problems resulting from the double helix, topoisomerases are bound to single or double stranded DNA and cut the phosphate spine of the DNA. This untangles the DNA releasing the DNA spine again. Since the chemical composition of the DNA remains the same, the untangled DNAs are chemical isomers. Therefore, topoisomerases are isomerase enzymes which work on the DNA topology. The N-terminal domain is then preceded by a highly conserved, 421 amino acid core domain that contains all of the catalytic residues except the active site tyrosine. A protease-sensitive and poorly conserved linker domain